Amitriptyline is a tricyclic antidepressant that is commonly used as a pain medication for conditions such as migraines, neuropathic pain, and fibromyalgia.
Amitriptyline is a tricyclic antidepressant that is commonly used as a pain medication for conditions such as migraines, neuropathic pain, and fibromyalgia. It was approved for sale by the FDA in 1961 after passing clinical trials to prove its safety and efficacy. Over the last 5 years, it has been one of the top 100 most prescribed medications in the United States.
The cost of many medications has been steadily rising at traditional pharmacies over the last 10 years. As a response to this, there has been a massive increase in online pharmacies offering generic versions of medication at highly reduced prices. Many of these pharmacies do not even require customers to have a prescription.
Amitriptyline appears to primarily exert its analgesic effects by inhibiting norepinephrine reuptake, this action increases the levels of norepinephrine in the spinal cord. The alpha-2 adrenergic receptor has its basal activity increased by a rise in norepinephrine, which has the analgesic effect of boosting the transmission of gamma-aminobutyric acid. Research continues to try to fully understand why Amitriptyline is so effective for treating painful nerve conditions as the studies which have taken place so far have proved its efficacy without fully understanding how.
Amitriptyline is no different from any other drug in that with misuse comes a greater chance of encountering side effects. However, side effects can be experienced by anybody and can be much worse for people with allergies to any of the ingredients. Be sure to do some research before starting to use a new medicine. The list below contains some of the most common side effects:
For a full list of side effects and possible contraindications, check the Patient Information Leaflet that is connected to the webpage of this medication. Start on as low a dosage as possible and build until the desired effect is reached, this will reduce the chances of experiencing adverse reactions. If side effects last more than 24 hours, stop using the medication and talk to a doctor.
The fact that amitriptyline has been on sale for so long goes some way to explaining how safe it is thought to be by medical professionals when used appropriately. Whenever using a new medication as a course of treatment, the patient should put together a treatment plan. This may include dietary changes that are shown to alleviate swelling or pain and can reduce reliance on medication.
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Information Checked: 26th July 2022
Next Check Due: July 2023
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